9/13/2023 0 Comments Download vitamin d in skin![]() Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytes. Phospholipase cgamma1 is required for activation of store-operated channels in human keratinocytes. The extracellular calcium-sensing receptor is required for calcium- induced differentiation in human keratinocytes. Vitamin D, calcium, and epidermal differentiation. This review will examine the various functions of vitamin D and its receptor in the skin, and explore the mechanisms by which these functions are regulated.īikle DD, Pillai S. Different coregulators appear to be involved in different VDR regulated functions. ![]() Regulation of these actions is exerted by a number of different coregulator complexes including the coactivators vitamin D receptor interacting protein (DRIP) complex also known as Mediator and the steroid receptor coactivator (SRC) family (of which SRC 2 and 3 are found in keratincytes), the inhibitor hairless (Hr), and β-catenin whose impact on VDR function is complex. These include inhibition of proliferation, stimulation of differentiation including formation of the permeability barrier, promotion of innate immunity, regulation of the hair follicle cycle, and suppression of tumor formation. ![]() Numerous functions of the skin are regulated by vitamin D and/or its receptor. The keratinocytes of the skin are unique in being not only the primary source of vitamin D for the body, but in possessing both the enzymatic machinery to metabolize the vitamin D produced to active metabolites (in particular 1,25(OH) 2D) and the vitamin D receptor (VDR) that enables the keratinocytes to respond to the 1,25(OH) 2D thus generated.
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